Bio-nanoimaging: Protein Misfolding and Aggregation by Vladimir Uversky,Yuri Lyubchenko

By Vladimir Uversky,Yuri Lyubchenko

Bio-Nanoimaging: Protein Misfolding & Aggregation presents a special advent to either novel and demonstrated nanoimaging innovations for visualisation and characterization of misfolded and aggregated protein species. The e-book is split into 3 sections masking: - Nanotechnology and nanoimaging know-how, together with cryoelectron microscopy of beta(2)-microglobulin, learning amyloidogensis through be troubled; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, together with fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation procedures, together with a number of pathways of lysozyme aggregation, misfolded intermediate of a PDZ area, and micelle formation by means of human islet amyloid polypeptide

Protein misfolding and aggregation is a fast-growing frontier in molecular drugs and protein chemistry. comparable problems contain cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and various neurodegenerative ailments like Alzheimer's and Parkinson's. Nanoimaging expertise has proved an important in knowing protein-misfolding pathologies and in capability drug layout aimed toward the inhibition or reversal of protein aggregation. utilizing those applied sciences, researchers can visual display unit the aggregation approach, visualize protein aggregates and examine their properties.

  • Provides functional examples of nanoimaging study from top molecular biology, telephone biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs
  • Includes over two hundred colour photographs to demonstrate the facility of varied nanoimaging applied sciences
  • Focuses on nanoimaging recommendations utilized to protein misfolding and aggregation in molecular medicine

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